包皮环切术可降低阴茎HPV感染的机会

从而可以使男性当前性伴发生子宫颈癌的危险降低

  2002年4月10日──4月11日的《The New England Journal of Medicine》杂志报导的汇总资料研究结果显示,男性进行包皮环切术,可以降低其发生人类乳头瘤病毒感染的危险。对于有多个性伴的男性,包皮环切术似乎也可以降低他们目前单一性伴侣子宫颈癌的发病危险。

  国际癌症研究所多中心子宫颈癌研究小组的医师及其同事写道:「男性包皮环切术与男性阴茎HPV感染危险的降低,并且可以使有高危性伴的女性,宫颈癌的发生危险降低。」

  此研究小组将来自5个国家的7次关于子宫颈原位腺癌以及宫颈癌的病例对照研究,共1,913对配偶的资料,进行了汇总。PCR反应发现,未进行包皮环切术的男性HPV DNA的检出率为19.6%,而进行包皮环切术的患者检出率为5.5%。调整潜在的混杂因素后,包皮环切术可以使HPV感染的危险降低63%。对于有6个及以上性伴的男性,包皮环切术可以使其单一女性性伴侣的子宫颈癌发病危险降低68%。

  作者写道:「考虑到这些疾病在世界范围内对于公共卫生的影响,需要进行进一步的研究,以阐明常规包皮环切术能否降低HIV与HPV感染以及其它性传播疾病的的发生危险。」

Circumcision Reduces Penile HPV Infection

Lowers Cervical Cancer Risk in Current Female Partners

By Laurie Barclay, MD
WebMD Medical News

Reviewed by Gary D. Vogin, MD

April 10, 2002 -- Circumcised men have a lower risk of developing human papillomavirus (HPV) infection, according to pooled data published in the April 11 issue of The New England Journal of Medicine. In men with multiple partners, circumcision also appears to reduce risk of cervical cancer in their current monogamous partners.

"Male circumcision is associated with a reduced risk of genital HPV infection in men and with a reduced risk of cervical cancer in women with high-risk sexual partners," write Xavier Castellsague, MD, and colleagues from the International Agency for Research on Cancer Multicenter Cervical Cancer Study Group.

The group pooled data on 1,913 couples from seven case-control studies in five countries of cervical carcinoma in situ and cervical cancer. Polymerase chain-reaction assay detected penile HPV DNA in 19.6% of the uncircumcised men and in 5.5% of the circumcised men.

After adjustment for potential confounders, circumcision reduced risk of HPV infection by 63%. For men with six or more sexual partners, circumcision reduced risk of cervical cancer in their monogamous female partners by 68%.

"Given the worldwide effect of these diseases on public health, further study is needed to determine whether routine circumcision can reduce the risks of HIV and HPV infections and other sexually transmitted diseases," the authors write.

© 2002 WebMD Inc. All rights reserved.

    
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