高脂肪饮食与精子质量降低有关


  【24drs.com】根据在线发表于人类生殖(Human Reproduction)期刊的一篇研究,饮食脂肪量,特别是饱和脂肪量多的男性,不孕风险可能增加,食物中若富含omega-3脂肪酸饮食则有助于男性的生育力。
  
  Dartmouth医学院的Jill A. Attaman医师等人分析了在2006年12月至2010年8月间就诊于波士顿一处生育门诊的99名男性的实验室检查结果和问卷资料。
  
  他们发现,相较于脂肪摄取量最少者,脂肪摄取量最高男性的精子数降低了43%,精子浓度降低38%。摄取omega-3脂肪酸最多的男性,正常精子比率比摄取omega-3最少者多2%;精子数和样本的精子总量有关,精子浓度则是代表每单位体积的精子数。
  
  摄取的脂肪种类造成这些差异,摄取的饱和脂肪增加5%,且相对的减少碳水化合物摄取,与精子总数降低38%有关,而不饱和或多元不饱和脂肪的增加对于精子数没有造成影响。
  
  作者们的结果是根据精子实验室分析数据和有131题的饮食频率问卷资料,问卷题目包括,平均而言,他们多常摄取某些食物、饮料、饮食补充品,选项包括从未食用到每天6次以上,研究者使用世界卫生组织的参考指标。
  
  虽然71%的研究对象是过重或肥胖,研究者区别了独立因素并指出,比率上和一般人的过重及肥胖比率(74%)几乎相同。
  
  不孕症影响了试图受孕之比率约为10%-15%。根据之前的研究,男性生育问题的因素约占40%-60%,约20%为其主因。虽然抽菸、喝酒、肥胖、药物滥用等与男性不孕有各种关联,但发表的研究很少探讨饮食因素的影响。
  
  研究者写道,就我们所知,这是迄今探讨特定饮食脂肪对于男性生育率之影响的最大型研究,也是第一篇有关饮食脂肪和精子质量之关联的报告;不过,研究限制包括,每个男性只有1份精子样本,食物问卷的填答可能不完全正确,意味著需要有后续研究来验证这些结果。
  
  Attaman医师在新闻稿中表示,同时,如果男性改变饮食、减少饱和脂肪量且增加摄取omega-3,这不只可以改善他们的一般健康,也可改善他们的生育力;整体而言,采纳这些生活型态改变可以改善一般健康。
  
  资料来源:http://www.24drs.com/professional/list/content.asp?x_idno=6758&x_classno=0&x_chkdelpoint=Y
  

Lower Semen Quality Associated With Higher-Fat Diets

By Larry Hand
Medscape Medical News

March 14, 2012 — Men who eat foods with high fat content, particularly saturated fat, may be risking their fertility, whereas men who eat foods rich in omega-3 fatty acids may be helping to maintain their fertility, according to a study published online March 13 in Human Reproduction.

Jill A. Attaman, MD, from Dartmouth School of Medicine in Hanover, New Hampshire, and colleagues analyzed the results of laboratory tests and questionnaire answers of 99 men attending a fertility clinic in Boston between December 2006 and August 2010.

They found that men who had the highest intake of fat had a 43% lower sperm count and a 38% lower sperm concentration than men who had the lowest intake of fat. Men who had the highest intake of omega-3 fatty acids had about 2% more normal sperm than men with the lowest intake of omega-3. Sperm count relates the total number of sperm in the sample, whereas sperm concentration refers to the number of sperm per unit volume.

The type of fat consumed appeared to make a difference: A 5% increase in saturated fat intake with a correspondingly lower intake of carbohydrates was associated with a 38% lower total sperm count, whereas a comparable increase in unsaturated or polyunsaturated fat made no difference in sperm count.

The authors' findings are based on semen laboratory analyses and administration of a 131-item food frequency questionnaire in which the men were asked to specify how often, on average, they consumed certain foods, beverages, and dietary supplements, with options ranging from never to 6 or more times a day. The researchers used World Health Organization reference points.

Although 71% of the men in the study were either overweight or obese, the researchers isolated the independent factors and noted that the percentage is almost the same as the frequency of overweight and obesity among men in the general population (74%).

Infertility hampers about 10% to 15% of couples attempting to conceive. Male reproductive issues could be a factor from 40% to 60% of the time, and the sole cause in about 20% of the cases, according to previous research. Although smoking, alcohol intake, obesity, and drug abuse have been linked to male infertility with mixed results, little has been published about dietary factors that may be related.

"To our knowledge, this is the largest study to date examining the influence of specific dietary fats on male fertility.... [And] the first report of a relation between dietary fat and semen quality," the researchers write. However, limitations of the study, including having only 1 semen sample per man and the possibility that the food frequency questionnaire answers might not be totally accurate, means that the research findings need to be replicated in future studies.

"In the meantime, if men make changes to their diets so as to reduce the amount of saturated fat they eat and increase their omega-3 intake, then this may not only improve their general health, but could improve their reproductive health too," Dr. Attaman said in a news release. "At a global level, adopting these lifestyle modifications may improve general health."

Dr. Attaman performed the work as a clinical and research fellow at the Massachusetts General Hospital and an instructor in obstetrics, gynecology and reproductive biology at Harvard Medical School, Boston.

The study was supported by the National Institute of Environmental Health Sciences and the National Institute of Diabetes and Digestive Kidney Diseases. The authors have disclosed no relevant financial relationships.

Hum Reprod. Published online March 13, 2012.

    
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