减重后,记忆功能可增加?


  【24drs.com】根据一篇新研究的结果,接受减重手术的肥胖者,记忆功能改善。
  
  俄亥俄州Kent州立大学的研究者John Gunstad博士表示,这篇研究有两个重点希望大家记住。首先,这篇研究清楚显示,肥胖引起脑部出现不良改变,但是其中有些可以藉由减重恢复。其次,如果肥胖者需要有其它促进减重的动机,这就是了。
  
  Gunstad博士表示,他们的研究动机是,从之前的临床工作获得「减重是否可以改善记忆与专注力」的观念。
  
  他表示,他在罗德岛的布朗大学医学院任职时,和其它研究者探讨透过行为方式或减重手术减重。注意这些病患是否在认知功能检测中有同样的错误。
  
  在这篇研究中,研究者探讨了纳入「Longitudinal Assessment of Bariatric Surgery」这项研究的109名减重手术病患,以及41名没有进行任何减重手术的肥胖对照组。所有的研究对象在研究开始时与追踪12周时完成认知功能评估。
  
  Gunstad博士表示,研究对象的平均体重是300磅(136公斤),进行减重手术者在12周时减轻约50磅(22.7公斤)。
  
  开始时,许多减重手术病患的认知检测表现不佳,但是在12周时,他们的记忆与专注程度比对照组改善(P < .001),事实上,肥胖病患的记忆表现曾经明确衰退。
  
  Gunstad博士表示,减重手术病患许多与控制肥胖有关的检测结果都有所改善,包括多元记忆指数以及心理运动速度检测。此外,相较于有高血压者,没有高血压的手术病患在12周时有较佳的短期延迟回忆(P = .005)。
  
  他表示,我们知道进行减重手术者会明显减轻50磅(22.7公斤)以上,所以,研究者将追踪这些病患达术后2年,看他们是否持续减重、密切观察这段追踪期间所发生的状况。
  
  纽约大学Langone医学中心精神科医师Sudeepta Varma表示,这篇研究的结果令人振奋与鼓舞;知道这点有助于治疗肥胖病患,或许应与一线照护医师密切合作,并转介这些病患进行减重手术,这类手术是可尝试的选项,提供更多可运用的治疗方式。
  
  减重也可帮助肥胖病患改善忧郁。她指出,肥胖者的忧郁症比率高,现在,治疗肥胖也可治疗忧郁的可能性增加。这篇研究让我们有信心地说:认知功能衰退是可以改变的。
  
  资料来源:http://www.24drs.com/professional/list/content.asp?x_idno=6502&x_classno=0&x_chkdelpoint=Y
  

Lose Weight, Gain Memory Function?

By Fran Lowry
Medscape Medical News

April 19, 2011 — Obese individuals who undergo bariatric surgery show evidence of improved memory function, according to the results of a new study.

"There are 2 take-home messages from our research," lead study author John Gunstad, PhD, from Kent State University in Ohio, told Medscape Medical News.

"The first is that this very clearly demonstrates that obesity causes adverse changes to the brain but that some of these changes might be reversible through significant weight loss. The second is if obese individuals are looking for yet another reason to motivate them to lose weight, this is it."

Dr. Gunstad said he and his colleagues got the idea to study whether weight loss improved memory and concentration from previous clinical work.

"I was working at Brown University Medical School in Rhode Island with people who were looking to lose weight through behavioral means or weight loss surgery. I kept noticing that these patients would make the same mistakes on cognitive function tests," he said.

More Benefit With Time?

In this study he and his team studied 109 bariatric surgery patients who were enrolled in the Longitudinal Assessment of Bariatric Surgery project and 41 obese control subjects who were not having weight loss surgery. All subjects completed a cognitive evaluation at baseline and at 12 weeks of follow-up.

The average weight of the patients in the study was 300 lb. Those who had bariatric surgery lost about 50 lb by week 12, Dr. Gunstad said.

At baseline, many bariatric surgery patients showed impaired performance on cognitive testing, but at 12 weeks, they had demonstrated improved memory and concentration, compared with the control subjects (P < .001). In fact, the memory performance of the obese subjects had actually declined.

"Several test results improved in the bariatric surgery patients relative to the obese controls, including multiple memory indexes and a test of psychomotor speed," Dr. Gunstad said.

In addition, surgery patients without hypertension had better short delay recall at 12 weeks than those with hypertension (P = .005).

"We know that people who go through weight loss surgery are going to lose substantially more than just 50 lb, so we are going to follow these patients for up to 2 years after their surgery as they continue to lose weight to take a closer look at what happens over the course of time," he said.

Ray of Hope

For Sudeepta Varma, MD, a psychiatrist at New York University Langone Medical Center in New York City, the results of this study are exciting and encouraging.

"It is nice to know that if I am treating an obese patient, perhaps I should work closely with the primary care doctor and we should refer this patient for bariatric surgery. Such surgery may be an option to try. It gives us more tools to work with," she told Medscape Medical News.

Losing weight may also help improve depression in obese patients, she added.

"We see a high rate of depression in obesity. Now the possibility is raised that treating the obesity might treat the underlying depression. This study gives us a little bit of hope to say that declining cognitive function does not have to be this person’s destiny, that things can be changed," she said.

This study was supported by the National Institutes of Health. Dr. Gunstad and Dr. Varma have disclosed no relevant financial relationships.

Surg Obes Relat Dis. Published online October 4, 2010.

    
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