Echinacea对一般感冒的治疗可能不那么有效


  June 15, 2004 - 六月份的内科医学文献(Archives of Internal Medicine)有一项发表指出,紫锥花对一般感冒的治疗并没有那么有效,这个结果已经经过一项随机双盲性试验证实;不过,研究人员表示,还需要进行更多的配方及剂量试验,以证实这项说法。
  
  来自威斯康辛的Steven Yale医师及Kejian Liu博士表示,之前的研究指出,紫锥菊(Echinacea purpurea)可以刺激免疫系统的反应,以减轻上呼吸道感染的症状及病程;这种植物对感冒的早期症状,具有显著的舒缓效果,但是并没有什么预防的作用。
  
  在产生感冒症状的24小时内,有128位患者以随机分配的方式,服用紫锥花制剂100毫克,药物的获取是,以植物空心部份的汁液,经过冻乾压缩的程序来作成;另外,有一安慰剂组,投与乳糖安慰剂;用药频率为每日三次。
  试验持续到症状减轻,最多14天,结果发现,两组的患者,都有相似的年龄及性别分布,而且每年的感冒次数,及抽烟的状况也都差不多。
  
  两组的总症状评分(total subjective symptom score),或平均症状评分(mean individual symptom score)都是一样的;所评比的症状有打喷嚏、流鼻水、鼻塞、头痛、喉咙搔痒酸痛、声音嘶哑、肌肉疼痛及咳嗽等,症状的舒缓期也相似。
  
  受测者的数量不够多,是本试验的主要局限,以这样的数量作紫锥花的疗效试验可能还不够。
  
  研究人员表示,一些研究指出,紫锥花可以有效的舒缓感冒症状,并缩短病程,但是,对于这一点,他们用同样的试验却无法得到相同的结果;至于,是不是能够刺激免疫反应来对抗病毒的攻击,他们认为,仍需要以不同的剂量及成份(如花、叶、根或这些的混合物)来多作一些试验。

Echinacea May Not Be Effective

By Laurie Barclay, MD
Medscape Medical News

June 15, 2004 — Echinacea may not be effective for the common cold, according to the results of a randomized, double-blind trial published in the June 14 issue of the Archives of Internal Medicine. However, the investigators suggest that more studies of different preparations and doses may be needed to validate previous claims.

Echinacea purpurea stimulates the immune response and is promoted to reduce symptom severity and the duration of upper respiratory tract infections,” write Steven H. Yale, MD, and Kejian Liu, PhD, from Marshfield Clinic Research Foundation in Wisconsin. “Previous research suggests that Echinacea may be most effective at lessening the severity and duration of the common cold when taken early in the illness, and has little to no preventative benefit.”

Within 24 hours of cold symptom onset, 128 patients were enrolled and randomized to receive either 100 mg of E. purpurea as freeze-dried pressed juice from the aerial portion of the plant, or a lactose placebo three times daily until cold symptoms were relieved or until the end of 14 days, whichever came first. At enrollment, the groups were similar in sex and age distribution, time from symptom onset to enrollment in the study, average number of colds per year, and smoking history.

There was no difference between groups for either total subjective symptom scores (P range, .29 - .90) or mean individual symptom scores (P range, .09 - .93) for sneezing, nasal discharge, nasal congestion, headache, sore or scratchy throat, hoarseness, muscle aches, or cough. The time to resolution of symptoms was also similar in both groups (P = .73).

The major study limitation, as with earlier studies, is the modest sample size, whicht may not be large enough to detect a smaller treatment effect of Echinacea.

“Some studies have concluded that Echinacea effectively reduces the symptoms and duration of the common cold. We were unable to replicate such findings,” the authors write. “Further investigation would be necessary to determine whether the dosage and composition (flower, leaves, roots, and/or a combination of species) can be adjusted to produce an immunostimulation that might be adequate to eliminate a viral challenge presented by the organisms responsible for the common cold.”

The Marshfield Clinic Research Foundation in Wisconsin was supported this study. The authors report no relevant financial interest in this article.

Arch Intern Med. 2004;164:1237-1241

Reviewed by Gary D. Vogin, MD

    
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