June 15, 2004 - 六月份的内科医学文献(Archives of Internal Medicine)有一项发表指出,紫锥花对一般感冒的治疗并没有那么有效,这个结果已经经过一项随机双盲性试验证实;不过,研究人员表示,还需要进行更多的配方及剂量试验,以证实这项说法。
  来自威斯康辛的Steven Yale医师及Kejian Liu博士表示,之前的研究指出,紫锥菊(Echinacea purpurea)可以刺激免疫系统的反应,以减轻上呼吸道感染的症状及病程;这种植物对感冒的早期症状,具有显著的舒缓效果,但是并没有什么预防的作用。
  两组的总症状评分(total subjective symptom score),或平均症状评分(mean individual symptom score)都是一样的;所评比的症状有打喷嚏、流鼻水、鼻塞、头痛、喉咙搔痒酸痛、声音嘶哑、肌肉疼痛及咳嗽等,症状的舒缓期也相似。

Echinacea May Not Be Effective

By Laurie Barclay, MD
Medscape Medical News

June 15, 2004 — Echinacea may not be effective for the common cold, according to the results of a randomized, double-blind trial published in the June 14 issue of the Archives of Internal Medicine. However, the investigators suggest that more studies of different preparations and doses may be needed to validate previous claims.

Echinacea purpurea stimulates the immune response and is promoted to reduce symptom severity and the duration of upper respiratory tract infections,” write Steven H. Yale, MD, and Kejian Liu, PhD, from Marshfield Clinic Research Foundation in Wisconsin. “Previous research suggests that Echinacea may be most effective at lessening the severity and duration of the common cold when taken early in the illness, and has little to no preventative benefit.”

Within 24 hours of cold symptom onset, 128 patients were enrolled and randomized to receive either 100 mg of E. purpurea as freeze-dried pressed juice from the aerial portion of the plant, or a lactose placebo three times daily until cold symptoms were relieved or until the end of 14 days, whichever came first. At enrollment, the groups were similar in sex and age distribution, time from symptom onset to enrollment in the study, average number of colds per year, and smoking history.

There was no difference between groups for either total subjective symptom scores (P range, .29 - .90) or mean individual symptom scores (P range, .09 - .93) for sneezing, nasal discharge, nasal congestion, headache, sore or scratchy throat, hoarseness, muscle aches, or cough. The time to resolution of symptoms was also similar in both groups (P = .73).

The major study limitation, as with earlier studies, is the modest sample size, whicht may not be large enough to detect a smaller treatment effect of Echinacea.

“Some studies have concluded that Echinacea effectively reduces the symptoms and duration of the common cold. We were unable to replicate such findings,” the authors write. “Further investigation would be necessary to determine whether the dosage and composition (flower, leaves, roots, and/or a combination of species) can be adjusted to produce an immunostimulation that might be adequate to eliminate a viral challenge presented by the organisms responsible for the common cold.”

The Marshfield Clinic Research Foundation in Wisconsin was supported this study. The authors report no relevant financial interest in this article.

Arch Intern Med. 2004;164:1237-1241

Reviewed by Gary D. Vogin, MD

2014/1/13 上午 11:26:29
2012/8/9 上午 11:03:51
2012/5/4 上午 11:28:08

   1   2   3   4   5   6   7   8