Sept. 9, 2003 -根据一篇发表于9月号Obstetrics & Gynecology的研究结果显示,荷尔蒙替代疗法 (HRT)可能可以减少人们罹患与抽烟有关的癌症机率。
  研究中显示,有抽烟习惯同时长期使用HRT的女性,较同样抽烟的妇女罹患相关癌症的发生率降低,包括口腔癌、咽癌、下咽、喉、食道、肺、子宫和膀胱癌(发生率标准化,0.24 ;95% 信赖区间 [ CI ]。0.08-0.76),其中受试者所使用的HRT和抽的香烟数并未影响这项研究结果。

HRT May Protect Against Smokin

By Laurie Barclay, MD
Medscape Medical News

Sept. 9, 2003 — Hormone replacement therapy (HRT) may protect against smoking-associated cancers, according to the results of a study published in the September issue of Obstetrics & Gynecology.

"We hypothesized that HRT use would favorably affect those epithelial tissues for which smoking is a carcinogen," write H. Olsson, MD, PhD, and colleagues from University Hospital in Lund, Sweden. "Specifically, HRT would maintain epithelial thickness and integrity, thus counteracting tumor development."

From 1990 to 1992, the investigators conducted baseline interviews in 29,508 Swedish women aged 25 to 65 years with no history of cancer. When follow-up ended on Dec. 31, 1999, 1,145 malignancies had been diagnosed. Women who went through natural menopause and had ever used HRT had no increased incidence of cancer overall.

Women who smoked and who used HRT long-term had a decreased incidence of smoking-related cancers, including cancer of the oral cavity, pharynx, hypopharynx, larynx, esophagus, lung, cervix, and bladder (standardized incidence ratio, 0.24; 95% confidence interval [CI]. 0.08 - 0.76). The type of HRT used and number of cigarettes smoked did not affect this finding.

HRT appeared to protect against colon cancer in both smokers and nonsmokers. Nonsmokers who used HRT had an increased incidence of endometrial cancer.

Because of study limitations, including relatively small sample size and limited follow-up, the authors recommend confirmation in future studies.

"The purpose of this report is not to advocate that women should smoke," the authors write. "We recommend that women use HRT as appropriate by the evolving standard of care and refrain from smoking."

The Swedish Cancer Society, Lund University, and the Gunnar Nillson Foundation helped support this study.

Obstet Gynecol. 2003;102:565-570

Reviewed by Gary D. Vogin, MD

2016/7/29 下午 02:55:42
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