最新的研究发现桡足类动物是重要的过敏原


Nov. 18, 2002─根据美国过敏气喘及免疫学院11月17日举办的第60届年会中所发表的研究报告,普遍存在于全球各地的桡足类动物,已逐渐成为威胁全球的新过敏原。
  
  威斯康辛医学院Steve Kagen博士说,桡足类动物是一种极微小的水生动物,分布在全球各种自然环境中,在我们的研究之前,桡足类动物从未被当成人类过敏源来做研究。
  
  这些部分寄生性的生物与甲壳纲动物具有远亲关系,例如小虾、龙虾及螃蟹等,它们会抑制深海海洋、淡水湖泊、温泉、河流、池塘的浮游生物食物链,甚至连小水滴也不放过。
  
  Dr. Kagen的研究团队利用胶体电泳、免疫转渍法(immunoblotting),或直接做酵素结合免疫吸附法(ELISA)来研究海洋中的一种桡足类动物Pseudocalanus elongates。结果发现在34种P. elongates蛋白中,有3种蛋白会抑制人类IgE的作用;而ELISA的抑制研究中,这些过敏原与各种食物,及受测试的吸入性过敏原间,并未显示交叉反应。在75个随机选取的遗传性过敏血清中,有33 (44%)个对桡足类动物具有专一性的IgE反应,这在克隆氏症(Crohn's disease)患者身上也有同样的情形发生。
  
  这是第一次发现桡足类动物会诱导人类的IgE免疫反应,因此桡足类动物很可能是各种过敏性疾病的重要致病原因,尤其它们普遍存在于地球各个地区,而且部分还具有寄生的生活特性。
  
  仍在进行中的研究将会决定这3种桡足类动物过敏原的胺基酸序列,并研究在罹患克隆氏症的人口中,有多少盛行率会发生桡足类动物专一性的IgE反应,以评估桡足类动物与其它相关过敏原之间的交叉反应,及定义人类会经由什么样的途径暴露在这种新发现且重要的全球性过敏原来源之中。
  
  
  
  
  

Copepods Newly Recognized as S

By Laurie Barclay, MD
Medscape Medical News

Nov. 18, 2002 — Copepods, one of the most abundant forms of animal life, are emerging as a new worldwide source of allergy, according to a presentation on Nov. 17 at the American College of Allergy, Asthma & Immunology Annual Meeting.

"Copepods are tiny aquatic animals distributed worldwide throughout nature," write Steve Kagen, MD, from the Medical College of Wisconsin, Appleton, and colleagues. "Prior to our studies, copepods have never before been studied as a cause of human allergy."

These partly parasitic creatures are distantly related to crustaceans such as shrimp, lobster, and crab, and they inhabit deep sea oceans as part of the plankton food chain, fresh water lakes, thermal pools, rivers, wells, ponds, and even water droplets clinging to leaves.

Dr. Kagen's group studied a pure sample of the ocean dwelling copepod Pseudocalanus elongates using gel electrophoresis, immunoblotting, and direct ELISA. Three of the 34 P. elongates proteins bound human IgE. ELISA inhibition studies revealed no cross-reactivity between these allergens and various food and inhalant allergens tested. Copepod-specific IgE was present in 33 (44%) of 75 randomly selected atopic sera studied, as well as in a patient with Crohn's disease.

"This is the first discovery to reveal that copepods induce specific IgE immune responses in humans," the authors write. "Copepods may be an important cause of allergic diseases, especially as they are ubiquitously distributed on Earth, and because they are in part parasitic in origin."

Ongoing research will determine the amino acid sequences of the three copepod allergens, study the prevalence of copepod-specific IgE reactivity in Crohn's disease, evaluate copepod cross-reactivity with other related allergens, and define the routes of human exposure to this new and important worldwide source of allergens.

ACAAI Annual Meeting: Concurrent Session 1. Presented Nov. 17, 2002.

Reviewed by Gary D. Vogin, MD

    
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