运动程度高与女性的气喘控制不佳有关


  【24drs.com】一篇纳入526名青少年和年轻人询问其运动程度的研究中,研究者发现,相较于中度运动者,高度运动与女性的气喘控制不佳有关,男性无此关联。
  
  瑞典Uppsala大学医学科学临床生理学系Ludvig Lovstrom在新闻稿中表示,重点在于高度运动而非极端运动,在我们的病患资料中,有三分之一的女孩运动量就是这么多。尽管如此,我们发现了这些结果,并且有这么明显的性别差异。
  
  这些在线发表于11月19日的Respirology期刊的研究结果认为,健康照护专业人士应格外注意高度运动女性的气喘治疗。
  
  诊断有气喘、年龄10-34岁的408名病患,答复了有关运动频率和/或时间的问卷,也进行了气喘控制测试、肺功能检查、乙酰甲基胆碱挑战、呼出气一氧化氮测定等,借以测量他们的气喘控制。
  
  对照组是118名年龄与性别配对、没有气喘者,随机选自人口登记资料,这些对照组对象也回答了上述问题。
  
  根据两部份的问卷测定运动程度,「你通常多常运动到呼吸急促或开始冒汗?(频率)」,以及「你每周有多少小时运动到呼吸急促或开始冒汗?(时间)」
  
  我们对运动频率和时间都定义了三种程度:频率高(每周≧4次)、中(每周1 – 3次)与低(每个月1次或更少),以及时间高(每周≧4小时)、中(每周1 – 3小时)、和低(每周约半小时或更少) 。
  
  Lovstrom医师等人发现,频率中等女性的气喘控制测试分数小于20分(未达目标)的胜算比为4.81 (95%信赖区间:2.43 - 9.51),而男性并未发现这类影响(胜算比:1.18;95%信赖区间:0.61 - 2.30)。
  
  他们也发现,在开始研究的前3个月期间,尽管有类似的局部或全身性发炎与支气管反应,高度运动女性的气喘发作高于中度运动的同侪。
  
  研究者表示,还不清楚是否与呼吸道直径大小或其它观点有关,或者只是因为气喘女性本身的呼吸道造成较容易气喘发作。
  
  资料来源:http://www.24drs.com/
  
  Native link:High Physical Activity Tied to Poor Asthma Control in Females
  

High Physical Activity Tied to Poor Asthma Control in Females

By Marcia Frellick
Medscape Medical News

In a study of 526 adolescents and young adults who were asked about how much they exercised, researchers found that compared with moderate physical activity, high physical activity levels were linked with poorer asthma control in females, but not males.

"It is important to remember that the high level of activity means nothing extreme — in our patient material every third girl exercised that much. Still, we uncovered these results, and with such a distinct gender difference," Ludvig Lovstrom, from the Department of Medical Sciences, Clinical Physiology, Uppsala University, Sweden said in a news release.

The findings, which were published online November 19 in Respirology, suggest that healthcare professionals should pay extra attention to the treatment of asthma in highly active females.

A group of 408 patients diagnosed with asthma, aged 10 to 34 years, answered questions concerning frequency and/or duration of physical activity and undertook the Asthma Control Test, spirometry, methacholine challenges, and exhaled nitric oxide measurements to measure their asthma control.

A group of 118 age- and sex-matched subjects who did not have asthma, randomly chosen from the population registry, served as the control group and also answered the questions.

Physical activity levels were determined from a two-part questionnaire that asked, "How often do you usually exercise so much that you get out of breath or start sweating?" (frequency) and "How many hours a week do you usually exercise so much that you get out of breath or start sweating?" (duration).

Three levels of physical activity were defined for both frequency and duration: high (?4 times a week), moderate (1 - 3 times a week) and low (once a month or less) frequency, and high-level (?4 hours a week), moderate (1 - 3 hours a week), and low (about half an hour or less each week) duration.

Dr Lovstrom and colleagues found that frequently vs moderately active females had an odds ratio of 4.81 (95% confidence interval, 2.43 - 9.51) of having an Asthma Control Test score of less than 20, whereas no such effect was found in males (odds ratio, 1.18; 95% confidence interval, 0.61 - 2.30).

They also found that highly active females experienced asthma attacks more often than their moderately active peers during the 3 months before the study, despite similar levels of local or systemic inflammation and bronchial responsiveness.

The researchers say it is unclear whether this is related to airway diameter or differing perceptions, or whether airways in females with asthma are just more predisposed to asthma attacks.

This cross-sectional study was part of a project run within the framework of an industry–academy collaboration on Minimally Invasive Diagnostics for Asthma and Allergic Diseases (MIDAS). The MIDAS study was financially supported within the framework of an academy–industry collaboration initiated by the Swedish Governmental Agency for Innovation Systems, where Aerocrine AB and Thermo Fisher Scientific Immunodiagnostics were partners and cofinanced the program. One coauthor is an employee of Thermo Fisher Scientific. No other relevant financial relationships were disclosed.

Respirology. Published online November 19, 2015.

    
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